YANG-MING INSTITUTE OF BIOMEDICAL INFORMATICS
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chuan-hsiung-chang2
  • 職稱 副教授, 生物醫學資訊研究所
  • 學歷 美國南加州大學分子生物學博士
  • 辦公室 守仁樓三樓 311室
  • 電話 886-2-28267316
  • Email cchangat.pngym.edu.tw
  • 個人網頁 http://bmi.ym.edu.tw/wp/?page_id=32
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  • 比較基因體學 (Comparative Genomics)
  • 精準醫學 - 人類與相關微生物菌叢及病毒基因體 (Precision Medicine - Human, Microbiome and Virus Genomes)
  • 基因體設計與工程 (Genome Design and Engineering)
  • 合成生物學 (Synthetic Biology)
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  • 1. Journal Publications
    • Chung-Yuan Cheng, Wan-Ling Tseng, Ching-Fen Chang, Chuan-Hsiung Chang, Susan Shur-Fen Gau. (2020) A Deep Learning Approach for Missing Data Imputation of Rating Scales Assessing Attention-Deficit Hyperactivity Disorder. Frontiers in Psychiatry. Submitted.
    • Shiao-Wen LI, Koichi Watanabe, Chih-Chieh Hsu, Shiou-Huei Chao, Zheng-Hua Yang, Yan-Jun Lin, Chun-Chiang Chen, Yong-Mei Cao, Hsuan-Cheng Huang, Chuan-Hsiung Chang, Ying-Chieh Tsai. (2017) Bacterial composition and diversity in breast milk samples from mothers living in Taiwan and mainland China. Frontiers in Microbiology, 8:965.
    • Shiao-Wen Li, Yi-Sheng Chen, Yun-Shien Lee, Chih-Hsien Yang, Sirinat Srionnual,Hui-Chung Wu and Chuan-Hsiung Chang. (2017) Comparative genomic analysis of bacteriocin-producing Weissella cibaria 110. Appl Microbiol Biotechnol., 101(3):1227-1237.
    • I-Ting Lin, Yi-Ming Chiou, Yen-Chia Liang, Ching-Nan Lin, Wei-Sheng W. Sun, Shiaowen Li, Chuan-Hsiung Chang, Wan-Jr Syu and Jenn-Wei Chen. (2016) Unique clustering genes in the bacterial chromosome affecting the type-III secretion of enterohaemorrhagic Escherichia coli. Microbiology, 162: 1744–1754.
    • Ching-Fen Chang, Chwan-Chuen King, Cho-Hua Wan, Yun-Cheng Chang, Ta-Chien Chan, Chang-Chun David Lee, Po-Hao Borris Chou, Zheng-Rong Tiger Li, Yao-Tsun Li, Tzu-Jung Tseng, Pei-Fen Lee and Chuan-Hsiung Chang. (2016) Lessons from the Largest Epidemic of Avian Influenza Viruses in Taiwan, 2015. Avian Dis. 2016 May;60(1 Suppl):156-71.
    • Chi Yang and Chuan-Hsiung Chang. (2015) Exploring comprehensive within-motif dependence of transcription factor binding in Escherichia coli. Scientific Reports, 5: 17021.
    • Kidane Desta Gebreyesus and Chuan-Hsiung Chang. (2016) A New Computational Algorithm to Estimate Case Fatality Rate. International Conference of Computational Statistics and Data Engineering, WCE2016. Peer-reviewed paper accepted for oral presentation.
    • Kidane Desta Gebreyesus and Chuan-Hsiung Chang. (2016) Innovative Computational Advances for Disease Outbreaks. International Conference of Systems Biology and Bioengineering, WCE2016. Peer-reviewed paper accepted for oral presentation.
    • Kidane Desta Gebreyesus and Chuan-Hsiung Chang. (2015) Infectious Diseases Dynamics and Complexity: Multicompartment and Multivariate State-Space Modeling. Proceedings of the World Congress on Engineering and Computer Science 2015 (WCECS 2015) Vol II: pp.552-555. (ISBN: 978-988-14047-2-5).
    • Wei-Hsien Liu, Chih-Hsien Yang, Ching-Ting Lin, Shiao-Wen Li, Wei-Shen Cheng, Yi-Ping Jiang, Chien-Chen Wu, Chuan-Hsiung Chang, Ying-Chieh Tsai. (2015) Genome architecture of Lactobacillus plantarum PS128, a probiotic strain with potential immunomodulatory activity. Gut Pathogens, 7:22.
    • I-Hsuan Lin, Dow-Tien Chen, Yi-Feng Chang, Yu-Ling Lee, Chia-Hsin Su, Ching Cheng, Yi-Chien Tsai, Swee-Chuan Ng, Hsiao-Tan Chen, Mei-Chen Lee, Hong-Wei Chen, Shih-Hui Suen, Yu-Cheng Chen, Tze-Tze Liu, Chuan-Hsiung Chang, Ming-Ta Hsu. (2015) Hierarchical Clustering of Breast Cancer methylomes Revealed Differentially Methylated and Expressed Breast Cancer Genes. PLoS ONE, 10(2): e0118453.
    • Ni-Chun Chung, Ying -Hsueh Huang, Chuan-Hsiung Chang, James C Liao, Chih-Hsien Yang, Chien-Chang Chen, Ingrid Y Liu. (2015) Behavior training reverses asymmetry in hippocampal transcriptome of the Cav3.2 knockout mice. PLoS ONE, 10(3): e0118832.
    • Chih-Hsien Yang, Chien-Chen Wu, Wei-Shen Cheng, Ming-Chuan Chung, Ying-Chieh Tsai, and Chuan-Hsiung Chang. (2015) A17, the first sequenced strain of Lactococcus lactis subsp. cremoris with potential immunomodulatory functions. Genome Announcements, 12;3(1). pii: e01563-14.
    • Kevin Tsai and Chuan-Hsiung Chang. (2014) Diagnostics for Stochastic Genome-Scale Modeling via Model Slicing and Debugging. PLoS ONE 9(11): e110380.
    • Ashesh A. Saraiya, Wei Li, Jesse Wu, Chuan H. Chang, Ching C. Wang. (2014) The microRNAs in an Ancient Protist Repress the Variant-Specific Surface Protein Expression by Targeting the Entire Coding Sequence. PLoS Pathogens 10(2): e1003791.
    • Ching-Fen Chang, Chang-Hsien Lin and Chuan-Hsiung Chang. (2014) BioMetaDB: Ontology-based Classification and Extension of Biodatabases. A peer-reviewed paper accepted and published at Bioinformatics 2014 - The International Conference on Bioinformatics Models, Methods and Algorithms, pp. 156-163 (ISBN: 978-989-758-012-3).
    • Shiou-Huei Chao, Hui-Yu Huang, Chuan-Hsiung Chang, Chih-Hsien Yang, Wei-Shen Cheng, Ya-Huei Kang, Koichi Watanabe, Ying-Chieh Tsai. (2013) Microbial Diversity Analysis of Fermented Mung Beans (Lu-Doh-Huang) by Using Pyrosequencing and Culture Methods. PLoS ONE 8(5): e63816.
    • SY Chang, YS Chen, SF Pan, YS Lee, CH Chang, CH Chang, B Yu and HC Wu. (2013) Enterocin TW21, a novel bacteriocin from dochi-isolated Enterococcus faecium D081821. Journal of Applied Microbiology, 115(3):673-678.
    • Chi-ming Chiu, Chi-huan Chang, Shwu-fen Pan, Hui-chung Wu, Shiao-wen Li, Chuan-hsiung Chang, Yun-Shien Lee, Chih-ming Chiang, and Yisheng Chen. (2013) Draft Genome Sequence of Lactobacillus pobuzihii E100301T. Genome Announcements, 1: e00185-13.
    • Chi Yang, Tzu-Wen Huang, Shiau-Yi Wen, Chun-Yang Chang, Shih-Feng Tsai, Whei-Fen Wu and Chuan-Hsiung Chang. (2012) Genome-wide PhoB binding and gene expression profiles reveal the hierarchical gene regulatory network of phosphate starvation in Escherichia coli. PLoS ONE 7(10): e47314.
    • I-Hsuan Lin, Ming-Ta Hsu and Chuan-Hsiung Chang. (2012) Protein domain repetition is enriched in Streptococcal cell-surface proteins. Genomics, 100(2): 370-379.
    • Pei-Hong Chen, Hsien-Lin Liu, Yin-Ju Chen, Yi-Hsiang Cheng, Wei-Ling Lin, Chien-Hung Yeh and Chuan-Hsiung Chang. (2012) Enhancing CO2 bio-mitigation by genetic engineering of cyanobacteria. Energy and Environmental Science, 5: 8318-8327.
    • Ko-Wen Wu, Chih-Yi Chien, Shiao-Wen Li, Chwan-Chuen King and Chuan-Hsiung Chang. (2012) Highly Conserved Influenza A Virus Epitope Sequences as Candidates of H3N2 Flu Vaccine Targets. Genomics, 100(2): 102-109.
    • Yi-Chang Liu, I-Hsuan Lin, Wei-Jen Chung, Wensi S. Hu, Wailap Victor Ng, Chi-Yu Lu, Tsung-Yen Huang, Hung-Wei Shu, Kwang-Jen Hsiao, Shih-Feng Tsai, Chuan-Hsiung Chang and Chao-Hsiung Lin. (2012) Proteomics Characterization of Cytoplasmic and Lipid-Associated Membrane Proteins of Human Pathogen Mycoplasma fermentans M64. PLoS ONE, 7(4): e35304.
    • Wei-Chao Liao, Wailap Victor Ng, I-Hsuan Lin, Wan-Jr Syu, Tze-Tze Liu and Chuan-Hsiung Chang. (2011) T4-Like Genome Organization of the Escherichia coli O157:H7 Lytic Phage AR1. Journal of Virology, 85(13): 6567–6578.
    • Yi-Feng Chang and Chuan-Hsiung Chang. (2011) CAGO: A Software Tool for Dynamic Visual Comparison and Correlation Measurement of Genome Organization. PLoS ONE, 6(11): e27080.
    • I-Hsuan Lin, Tze-Tze Liu, Yu-Ting Teng, Hui-Lun Wu, Yen-Ming Liu, Keh-Ming Wu, Chuan-Hsiung Chang and Ming-Ta Hsu. (2011) Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence. PLoS ONE, 6(5): e20519.
    • Yi-Chien Tsai, Chun-Hui Chiao, Ian Yi-Feng Chang, Dow-Tien Chen, Tze-Tze Liu, Kate Hua, Chuan-Hsiung Chang and Ming-Ta Hsu. (2011) Common Altered Epigenomic Domains in Cancer Cells: Characterization and Subtle Variations. Cancers, 3(2): 1996-2013.
    • Chih-Hsien Yang, De-Ming Lin, Li-Hsiang Yen, Wei-Chao Liao, Shiau-Yi Wen and Chuan-Hsiung Chang. (2010) Biosystem with Regulated Insulin Expression and Glucose Auto-Sensing for Diabetes. International Journal of Systems and Synthetic Biology, 1: 135-145.
    • Chiou-Jour Lai, Shau-Yan Chen, I-Hsuan Lin, Chuan-Hsiung Chang and Hin-chung Wong. (2009) Characterization of a New Plasmid-like Prophage in a Pandemic Vibrio parahaemolyticus O3:K6 strain. International Journal of Food Microbiology, 135: 118-124.
    • Shih-Feng Lan, Chung-Ho Huang, Chuan-Hsiung Chang, Wei-Chao Liao, I-Hsuan Lin, Wan-Neng Jian, Yueh-Gin Wu, Shau-Yan Chen and Hin-Chung Wong. (2009) Change of protein profiles in the induction of the viable but nonculturable state of Vibrio parahaemolyticus. Applied and Environmental Microbiology, 75: 2659–2667.
    • 楊志賢、吳傑熙、張傳雄. (2009) 合成生物學競賽— iGEM. 科學月刊 472(4): 294-297.
    • 廖威超、張傳雄. (2009) 生物安全防禦與倫理. 科學月刊 472(4): 298-301.
    • 張益峰、楊志賢、張傳雄. (2009) 構築生命的藍圖:合成生物學的研究與發展. 科學月刊 472(4): 280-288.
    • Si-Huei Wu, Yau-Hung Chen, Fong-Lee Huang, Chuan-Hsiung Chang, Yi-Feng Chang and Huey-Jen Tsay. (2008) Multiple Regulatory Elements Mediating Neuronal-Specific Expression of Zebrafish Sodium Channel Gene, Scn8aa. Developmental Dynamics, 237:2554-2565.
    • Chung-Te Lee,Carmen Amaro,Keh-Ming Wu,Esmeralda Valiente,Yi-Feng Chang, Shih-Feng Tsai, Chuan-Hsiung Chang, Lien-I Hor. (2008) A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid. Journal of Bacteriology, 190(5):1638-1648.
    • Chang, C. J., Chiu, J. H., Tseng, L. M., Chang, C. H., Chien, T. M., Wu, C. W. & Lui, W. Y. (2006) Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. European Journal of Clinical Investigation 36(8):588-596.
    • Chun-Ju Chang, Jen-Hwey Chiu, Ling-Ming Tseng, Chuan-Hsiung Chang, Tsu-Ming Chien, Chien-Chih Chen, Chew-Wun Wu, Wing-Yiu Lui. (2006) Si-Wu-Tang and its constituents promote mammary duct cell proliferation by up-regulation of HER-2 signaling. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 13(6):967-976.
    • Chang Y-C and Chang C-H. (2003) Common Repeat Sequences in Bacterial Genomes. Journal of Medical and Biological Engineering 23:65-72.
    • Chen C-Y, Wu K-M, Liao T-L, Chang Y-C, Chang C-H, Tsai H-C, Liu Y-M, Tsen T-Y, Chen H-J, Li J-C, Su T-L, Su J-S, Chen T-T, Shen Arthur B-T, Shao C-P, Lee C-T, Hor L-I, and Tsai S-F. (2003) Comparative Genome Analysis of Vibrio vulnificus, a Marine Pathogen. Genome Research 13:2577-2587.
    • Neve RM, Ylstra B, Chang C-H, Albertson DG, and Benz CC. (2002) ErbB2 Activation of ESX gene expression. Oncogene 30:3934-3938.
    • Scott GK, Chang C-H, Erny K, Xu F, Fredericks WJ, Rauscher FJ, Thor AD, and Benz CC. (2000) Ets regulation of the erbB2 promoter. Oncogene 19:6490-6502.
    • Lin CS, Lau A, Yeh CC, Chang C-H, and Lue TF. (2000) Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences. DNA AND CELL BIOLOGY 19:1-7.
    • Chang C-H, Scott GK, Baldwin MA, and Benz CC. (1999) Exon 4-encoded Acidic Domain in the Epithelium-restricted Ets Factor, ESX, confers Potent Transactivating Capacity and binds to TATA-binding Protein (TBP). Oncogene 18:3682-3695.
    • Liang X, Lu B, Scott GK, Chang C-H, Baldwin MA, and Benz CC. (1998) Oxidant Stress Impaired DNA-binding of Estrogen Receptor from Human Breast Cancer. MOLECULAR AND CELLULAR ENDOCRINOLOGY 146:151-161.
    • Neve R, Chang C-H, Scott GK, Wong A, Friis RR, Hynes NE, and Benz CC. (1998) The Epithelium-specific Ets Transcription Factor ESX is Associated with Mammary Gland Development and Involution. FASEB JOURNAL 12:1541-1550.
    • Lu B, Liang X, Scott GK, Chang C-H, Baldwin MA, Thomas T, and Benz CC. (1998) Polyamine Inhibition of Estrogen Receptor DNA-Binding and Ligand-Binding Functions. BREAST CANCER RESEARCH AND TREATMENT 48:243-257.
    • Lin C-S, Chang C-H, and Huynh Truc. (1997) The Murine L-plastin Gene Promoter: Identification and Comparison with the Human L-plastin Gene Promoter. DNA AND CELL BIOLOGY 16:9-16.
    • Benz CC, O’Hagan RC, Richter B, Scott GK, Chang C-H, Xiong X, Chew K, Ljung BM, Edgerton S, Thor A, and Hassell JA. (1997) HER-2/neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer. Oncogene 15:1513-1525.
    • Chang C-H, Scott GK, Kuo W-L, Xiong X, Suzdaltseva Y, Park JW, Sayre P, Erny K, Gray JW, and Benz CC. (1997) ESX: A Structurally Unique Ets Overexpressed Early during Human Breast Tumorigenesis. Oncogene 14:1617-1622.
  • 2 . Conference Presentations
    • Chaun-Hsiung Chang. Sequencing and Data Analysis of Human Gut Microbiome (腸道菌叢之基因定序與分析). 微菌叢植入治療訓練課程,台北榮民總醫院致德樓, February 22, 2020.
    • Chaun-Hsiung Chang. Comparative Analysis of Microbial Whole Genomes. Microbiota NGS Bioinformatics Workshop. 微菌次世代定序資訊分析工作坊. Taipei, Taiwan, November 16, 2019.
    • Ching-Fen Chang and Chuan-Hsiung Chang, Design and Engineering of Diverse Protein Functions with Protein Domain Combinations. The 14th Asian Congress on Biotechnology in Conjunction with 2019 BEST Conference & International Symposium on Biotechnology and Bioengineering, 2019.
    • Chung-Yuan Cheng, Ching-Fen Chang , Chuan-Hsiung Chang, Susan Shur-Fen Gau. A Deep Learning Based Approach for Missing Data Imputation in Atten tion Deficit Hyperactivity Disorder. The 7th World Congress on ADHD: From Child to Adult Disorder. Lisbon, Portugal, 25-28 April 2019.
    • Ching-Fen Chang and Chuan-Hsiung Chang, Profiling of Human Microbiome With Comparative Genomics.微菌重叢應用與數據分析研討會 Aging and Disease Prevention Research Center, Fooyin University, 19 November 2018.
    • Chung-Yuan Cheng, Ching-Fen Chang , Chuan-Hsiung Chang and Susan Shur-Fen Gau. Validation of attention deficit/hyperactivity disorder by clinical symptoms and attention performance: A machine learning approach. The 17th Taiwanese Society of Child and Adolescent Psychiatry (TSCAP) Annual Meeting, 2015,
    • Ching-Fen Chang , Chang-Hsien Lin and Chuan-Hsiung Chang. BioMetaDB: Ontology based Classification and Extension of Biodatabases. pp. 156 163. BIOINFORMATICS 2014 Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms. Angers, Loire Valley, France, 2014. (Conference Paper)
    • Ching-Fen Chang , Tzu-Ting Chen and Chuan-Hsiung Chang. Domain Combination Based Logic Design of Synthetic Protein Functions. The 2014 IUBMB (International Union of Biochemistry and Molecular Biology)conference, Academia Sinica, Taipei, Taiwan, 2014.
    • Ching-Fen Chang and Chuan-Hsiung Chang. Transforming Medicine and Health Care with Genomic Big Data Revolution. The 9th Medicine and Health Care with Genomic Big Data Revolution. The 9th Asian–Pacific Conference on Medical and Biological Engineering (APCMBE Pacific Conference on Medical and Biological Engineering (APCMBE 2014). National Cheng Kung University, Tainan, Taiwan, 20142014). National Cheng Kung University, Tainan, Taiwan, 2014.
    • Kevin Tsai and Chuan-Hsiung Chang. Debugging Platform for Iterative Design of Model-Based Synthetic Genomes. Synthetic Biology 6.0 (The Sixth International Meeting on Synthetic Biology), Imperial College, London, UK, 2013.
    • Kevin Tsai and Chuan-Hsiung Chang. Debugging Platform for Iterative Design of Whole Genomes. Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways. Colorado, USA, 2013.
    • Chih-Hsien Yang, Yi-Feng Chang, Ying-Hsueh Huang, Chi Yang, Jesse Wu, Kevin Tsai and Chuan-Hsiung Chang. GenomeCAD: Computer-Aided Design of Microbial Genomes and Interaction Networks. 6th IECA Conference on Synthetic Biology with applications to biotechnology, Taipei, Taiwan, 2012.
    • Chih-Hsien Yang and Chuan-Hsiung Chang. SBNL and an Interaction-based Design Approach for Microbial Genomes. 6th IECA Conference on Synthetic Biology with applications to biotechnology, Taipei, Taiwan, 2012.
    • Pei-Hong Chen, Chih-Hsien Yang and Chuan-Hsiung Chang. Big Data based Analysis, Design and Engineering of the Blueprint of Microalgal Life. Annual Conference of Taiwan Phycological Society, Taipei, Taiwan, 2012.
    • Chuan-Hsiung Chang. Big Data Based Bio-CCS for Analysis, Design and Engineering of Microalgae. 2012 Taiwan Symposium on Carbon Dioxide Capture, Storage and Utilization. NSC Clean Coal Master Project, Taipei, Taiwan, 2012.
    • Yi-Feng Chang, Chih-Hsien Yang and Chuan-Hsiung Chang. Reverse Engineering of Genome Organization Rules for Genome Design. Bioinformatics and Systems Biology in Taiwan 2012 (BIT2012), Taipei, Taiwan, 2012.
    • Pei-Hong Chen, Hsien-Lin Liu, Yin-Ju Chen, Yi-Hsiang Cheng, Wei-Ling Lin, Chien-Hung Yeha and Chuan-Hsiung Chang. Enhancing CO2 bio-mitigation by genetic engineering of cyanobacteria. International Conference on Next Generation Technologies for Bioenergy and Biomass Utilisation. Singapore, 2012.
    • Chih-Hsien Yang, Jesse Wu, Chi Yang, Tao-Hsuan Chang and Chuan-Hsiung Chang. Network-based Genome Design and Engineering with Direct Logical-to-Physical Compilation. The fourth International Workshop on Bio-Design Automation (IWBDA) 2012 at The 49th Design Automation Conference (DAC) - IWBDA, San Francisco, CA, USA, 2012.
    • Chih-Hsien Yang and Chuan-Hsiung Chang. Synthetic Biological Network Language (SBNL). Synthetic Biology 5.0, Stanford University, USA, 2011.
    • Jesse Wu and Chuan-Hsiung Chang. Genome Watermarking System for Synthetic Genome Ownership. Synthetic Biology 5.0, Stanford University, USA, 2011.
    • Chih-Yi-Chien and Chuan-Hsiung Chang. Optimization of carbon fixation pathway for maximal carbon dioxide assimilation in cyanobacteria. Synthetic Biology 5.0, Stanford University, USA, 2011.
    • Pei-Hong Chen and Chuan-Hsiung Chang. High-efficient multiple-gene transformation in Synechococcus elongatus PCC 7942. Synthetic Biology 5.0, Stanford University, USA, 2011.
    • Pei-Hong Chen, Jian-Hong Ye, Ying-Ru Chen, Yi-Hsing Cheng and Chuan-Hsiung Chang. Developing a synthetic carbon fixation system in cyanobacteria. Cold Spring Harbor Asia Conferences: 2011 Symposium: Design & Synthesis of Biological Systems. Suzhou, China, 2011.
    • Pei-Hong Chen, Chih-Hsien Yang, Chuan-Hsiung Chang. Optimizing photosynthesis-based solar energy conversion in microorganisms through genome design and engineering. 15th International Congress of Photosynthesis. Beijing, China, 2010.
    • Pei-Hong Chen and Chuan-Hsiung Chang. Design and optimization of synthetic carbon fixation pathways in cyanobacteria. BioSensing and BioActuation Summer Institute. Illinois, USA, 2010.
    • Yi-Feng Chang, Chuan-Hsiung Chang. Cross-Species Comparison of Genometric Features by Wavelet Analysis. The 14th International Conference on Research in Computational Molecular Biology (RECOMB 2010), Lisbon, Portugal, 2010.
    • Wei-Chao Liao, Wailap Victor Ng, Chuan-Hsiung Chang. How T4-like Phages Organize Their Genomes. The 14th International Conference on Research in Computational Molecular Biology (RECOMB 2010), Lisbon, Portugal, 2010.
    • Shiao-Wen Li, Chuan-Hsiung Chang. BGEdb: A Multiscale Bacterial Gene Expression Database for Integrative Dynamics. The 14th International Conference on Research in Computational Molecular Biology (RECOMB 2010), Lisbon, Portugal, 2010.
    • Chuan-Hsiung Chang, Yi-Feng Chang, Chih-Hsien Yang, Ying-Hsueh Huang, Jesse Wu, Chi Yang, I-Hsuan Lin, Wei-Chao Liao. GenomeCAD - Computer Aided Whole Genome Design, BioFine 2009 - Europe: Applied Industrial Synthetic Biology international conference, Freiburg, Germany, 2009.
    • Chi Yang, Shiau-Yi Wen, Chuan-Hsiung Chang. Signal integration in the phosphate network of Escherichia coli. BioSysBio Conference 2009, University of Cambridge, UK, 2009.
    • I Hsuan Lin, Chuan-Hsiung Chang. Computational Analysis of Mycoplasma fermentans M64 Genome,BioSysBio Conference 2009,University of Cambridge, UK, 2009.
    • Chuan-Hsiung Chang. GenomeCAD - Computer Aided Whole Genome Design. BioKorea 2009, Seoul, Korea, 2009.
    • Ying-Hsueh Huang, Chien-Chi Lo, Wen-Ching Chan, Wei-Xuan Lo, Chih-Hsien Yang, Chi Yang, Ching-Hung Tzeng, Tien-Chueh Kuo and Chuan-Hsiung Chang. Towards the whole picture of an entire cellular system: Accessing genome-scale system properties of Escherichia coli K-12 through an integrated interaction network.,Genomes 2008 - Functional Genomics of Microorganisms, Institute Pasteur, Paris, France, 2008.
    • Chuan-Hsiung Chang, Chih-Hsien Yang, Yi-Feng Chang, Ying-Hsueh Huang, Jesse Wu, Chi Yang, Kun-Yi Chou, You-Hua Cheng. GenomeCAD - Computer Aided Whole Genome Design. Synthetic Biology 4.0, Hong Kong, 2008.
    • Ying-Hsueh Huang, Chien-Chi Lo, Wen-Ching Chan, Wei-Xuan Lo, Chih-Hsien Yang, Chi Yang, Ching-Hung Tzeng, Tien-Chueh Kuo, Yi-Feng Chang, Chuan-Hsiung Chang. INCO: An Integrated Interaction Network of Escherichia coli K-12 MG1655, Microbial Genomes 2007, Hinxton, UK, 2007.
    • Yang Chih-Hsien and Chuan-Hsiung Chang, Duplication Modules in Photosynthetic Cyanobacterial Proteomes,10th Annual International Conference on Research in Computational Molecular Biology (RECOMB),Italy,2006
    • Lo, Eric Wei-Xuan and Chang Chuan-Hsiung, Conservation of mitochondrial regulatory elements in sequenced mitochondrial genomes, 10th Annual International Conference on Research in Computational Molecular Biology (RECOMB), Italy, 2006.
    • Liao Wei-Chao, Ng Wailap Victor, and Chang Chuan-Hsiung, Distinct Grouping and Genome Organization among Escherichia coli Bacteriophages, 10th Annual International Conference on Research in Computational Molecular Biology (RECOMB), Italy, 2006.
    • Lin Yu-Hsuan and Chang Chuan-Hsiung, Phylogenetic Analysis with Metabolic Profiles, 10th Annual International Conference on Research in Computational Molecular Biology (RECOMB), Italy, 2006.
    • Chang Y-F and Chang C-H, Identification and Characterization of Conserved Overlapping Genes in Vibrio Genomes,9th Annual International Conference on Research in Computational Molecular Biology (RECOMB), USA, 2005.
    • Lo W-X, Yamada1 T, Tanaka1 M, Hattori M, Goto S, Kanehisa M, and Chang C-H, A method for customized cross-species metabolic pathway comparison, The 15th International Conference on Genome Informatics, Japan, 2004.
    • Chen C-Y and Chang C-H., CAMP – a computational system for Comparative Analysis of Metabolic Pathways. (2004) 8th Annual International Conference on Research in Computational Molecular Biology (RECOMB). 8th Annual International Conference on Research in Computational Molecular Biology (RECOMB), USA, 2004.
    • Chen H-W, Chang Y-C, Liou D-M, and Chang C-H., Conservation profiling of functionally-coupled gene clusters through multiple genome comparison. (2004) 12th International Conference on Intelligent Systems for Molecular Biology (ISMB). 12th International Conference on Intelligent Systems for Molecular Biology (ISMB), The United Kingdom, 2004.
    • Lin Y-C, Chu C-H, and Chang C-H., Comparative analysis of mycoplasmal replication origins. (2004) Taiwan Bacteriology Symposium., Taiwan Bacteriology Symposium, Taiwan, 2004.
    • Chang Y-F, Lin T-I, and Chang C-H., CAGO: a computational system for Comparative Analysis of Genome Organization. (2004) Taiwan Bacteriology Symposium., Taiwan Bacteriology Symposium, Taiwan, 2004.
    • Chao Y, Walther A, Baldwin MA, Chang C-H, Scott GK, Wold MS, and Benz CC., An Epithelium-restricted ETS factor, ESX/ELF3, can assemble both transcription and replication complexes. (2000) Amer. Assoc. Cancer Res. 41:3976. American Association for Cancer Research annual conference, USA, 2000.
    • Pan CC, Lin JH, Wu JD, Chang YS, Chang CJ, Tyan MC, Leu CY, Chang YC, Huang JL, and Chang CH., FeverChip for fever-causing pathogen detection and identification. (2001) IBC CHIPS TO HITS CONFERENCE. IBC CHIPS TO HITS CONFERENCE, USA, 2000.
    • Chang C-H, Scott GK, Semyonov J, Chao Y, and Benz CC., Exon 4 and 7 encode Separate Transactivating and Chromatin Localizing Domains in ESX, an Ets Transactivator linked to Mammary Gland Development and Tumorigenesis. (1999) Amer. Assoc. Cancer Res. 40: 131. American Association for Cancer Research annual conference, USA, 1999.
    • Scott GK, Chang C-H, Xiong X, Ren S, Park JW, and Benz CC., Targeting Ets-linked Promoter Structure to Repress erbB2 transcription. (1998) Amer. Assoc. Cancer Res. 39: 180. American Association for Cancer Research annual conference, USA, 1998.
    • Chang C-H, Scott GK, Xiong X, Rauscher FR, and Benz CC., Development of chimeric DNA-binding repressors to silence HER2/neu gene expression. (1997) Amer. Assoc. Cancer Res. 38: 2334. American Association for Cancer Research annual conference, USA, 1997.
    • O’Hagan RC, Richter B, Scott GK, Chang C-H, Xiong X, Chew K, Ljung BM, Edgerton S, Thor A, Hassell JA, and Benz CC., Activation of HER2/neu Kinase induces Overexpression of the Ets-related Transcription Factor PEA3. (1996) Amer. Assoc. Cancer Res. 37: 522. American Association for Cancer Research annual conference, USA, 1996.
    • Chang C-H, Scott GK, Xiong X, Hurst H, and Benz CC., ETS and OB2-1 Factors mediate Transcriptional Overexpression of HER2/neu. (1995) Amer. Assoc. Cancer Res. 36: 532. American Association for Cancer Research annual conference, USA, 1995.
  • 3. Honors and Awards
    • Zoller-Landfear Breast Cancer Scholar Award
    • American Association for Cancer Research (AACR) Young Investigator Award
    • International Synthetic Biology iGEM Competition at MIT:
      • iGEM Asia Advisory Board Member
      • iGEM Synthetic Biology Competition - Asia and World Championship Judge
      • Gold Medal and Grand Finalist Awards
        • 2018 – Gold Medal
        • 2017 – Gold Medal
        • 2016 – Gold Medal
        • 2015 – Gold Medal
        • 2014 – Gold Medal
        • 2013 – Gold Medal, Best Environment Project Award, Finalist, Best Presentation, Best New BioBrick Engineered Part or Device, Best Parts Collection and Most Improved Registry Part
        • 2012 – Gold Medal, Best New Natural BioBrick Part
        • 2011 – Gold Medal
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