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  • 職稱:    主任, 國家衛生研究院分子與基因醫學研究組
  • 學歷:    美國紐約市立大學西奈山醫學院哲學博士
  • 辦公室:  國家衛生研究院
  • 電話:    886-2-28267043
  • Email:   petsaiat.pngnhri.org.tw
  • 個人網頁http://www.ym.edu.tw/~sftsai1/index.html
  • 人類遺傳學、基因體醫學
  • Journal Papers
    1. Tsai SF, Bishop DF, & Desnick RJ. (1987) Purification and properties of uroporphyrinogen III synthase from human erythrocytes. J. Biol. Chem. 262, 1268-1273.
    2. Tsai SF, Bishop DF, & Desnick RJ. (1987) Coupled-enzyme and direct assays for uroporphyrinogen III synthase activity in human erythrocytes and cultured lymphoblasts. Enzymatic diagnosis of heterozygotes and homozygotes with congenital erythropoietic porphyria. Anal. Biochem. 166, 120-133.
    3. Tsai SF, Bishop DF, & Desnick RJ. (1988) Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Proc. Natl. Acad. Sci. USA. 85, 7049-7053.
    4. Martin DIK, Tsai SF, & Orkin SH. (1989) Increased g-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA binding factor. Nature (London) 338, 435-438.
    5. Tsai SF, Martin DIK, Zon LI., D’Andrea AD, Wong G.G. & Orkin SH. (1989) Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (London) 339, 446-451.
    6. Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns G.A, & Orkin SH.(1990) The major human erythroid DNA-binding protein (GF-1): Primary sequence and localization of the gene to the X chromosome. Proc. Natl. Acad. Sci. USA. 87, 668-672.
    7. Whitelaw E, Tsai SF, Hogben P, & Orkin SH. (1990) Regulated expression of globin chains and the erythroid transcription factor (GF-1/NF-E1/Eryf1) during erythropoiesis in the developing mouse. Mol. Cell. Biol. 10: 6596-6606.
    8. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D’Agati V, Orkin SH, & Costantini F. (1991) A targeted mutation in the gene for transcription factor GATA-1 blocks erythroid differentiation in chimeric mice. Nature (London) 349: 257-260.
    9. Tsai SF, Strauss E, & Orkin SH. (1991) Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes & Dev. 5: 919-931.
    10. Ho IC, Vorhees P, Marin N, Karpinski Oakley B, Tsai SF, Orkin SH, & Leiden J M. (1991) Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor a gene. EMBO J. 10: 1187-1192.
    11. Astrin KH, Warner CA, Yoo HK, Goodfellow PJ, Tsai SF, & Desnick RJ. (1991) Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2 -q26.3. Hum. Genet. 87: 18-22.
    12. Warner CA, Poh-Fitzpatrick MB, Zaider EF, Tsai SF, & Desnick RJ. (1992) Congenital erythropoietic porphyria, A mild variant with low uroporphyrin I level due to a missense mutation (A66V) encoding residual uroporphyrinogen III synthase activity. Arch. Dermatol. 128: 1243-1248.
    13. Pai JT, Tsai SF, Horng CJ, Chiu PC, Cheng MY, Hsiao KJ, & Wu KD. (1994) Absence of FMR-1 gene expression can be detected with RNA extracted from dried blood specimens. Hum. Genet. 93: 488-493.
    14. Skoda RC, Tsai SF, Orkin SH, & Leder P. (1995) Expression of c-MYC under the control of GATA-1 Regulatory sequences causes erythroleukemia in transgenic mice. J. Exp. Med. 181: 1603-1613.
    15. Lin WH, Huang LH., Yeh JY, Hoheisel J, Lehrach H, Sun YH, & Tsai SF. (1995) Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region. J. Biol. Chem. 27: 25150-25158.
    16. Lee DD, Huang JY, Wong CK., Gagel RF, & Tsai SF. (1996) Genetic heterogeneity of familial primary cutaneous amyloidosis: Lack of evidence for linkage with the chromosome 10 pericentromeric region in Chinese families. J. Inv. Derma. 107: 30-33.
    17. Tsai SF, Jang A CC, Prikhod’Ko G., Bessarab DA, Tang CY, Pflugfelder GO, & Sun YH. (1997) Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila . Proc. Natl. Acad. Sci. USA. 94: 3837-3841.
    18. Fan FF, Shen HH, Tseng WP, Chen PM, & Tsai SF. Molecular cloning and characterization of a human brain-specific gene implicated in neuronal differentiation. (1998) Molecular Brain Research 54: 113-123.
    19. Tsou AP, Wu KM, Tseng TI, Chi CW, Chiu JW, Lui WY, Hu CP, Chang C, Chou,CK, & Tsai SF. Parallel hybridization analysis of multiple protein kinase genes: identification of gene expression patterns characteristic of human hepatocellular carcinoma. (1998) Genomics 50: 331-340.
    20. Chen YJ, Chen PJ, Shu CH, Hsu MT, Tsai SF, & Lin CH. Chromosomal aberrations in nasopharyngeal carcinoma analyzed by comparative genomic hybridization. (1999) Genes Chromosomes and Cancer 25:169-175.
    21. Chen YJ, Yeh SH., Chen JT, Wu CC, Hsu MT, Tsai SF, Chen PJ, & Lin CH. Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma. (2000) Gastroenterology 119(2):431-440.
    22. Tsai SF, & Chen PJ. The impact of human genome research on medicine — The initial Taiwan Experience. (2000) Journal of the Formosan Medical Association 99(2):107-115.
    23. Bressler J, Tsai TF, Wu MY, Tsai, SF, Ramirez MA, Armstrong D, & Beaudet AL. The SNRPN prrmoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. (2001) Nat. Genet. 28:232-240.
    24. Shen HH, Huang AM, Hoheisel J, & Tsai SF. Identification and characterization of a SET/NAP protein encoded by the brain-specific gene, MB20. (2001) Genomics 71(1): 21-33.
    25. Chang YT, Tsai SF, Wang WJ, Hong CJ, Huang CY, & Wong CK. A study of apolipoproteins E and A-l in cutaneous amyloids. (2001) Br. J. Dermatol. 145:422-427.
    26. Fujiyama A, Watanabe H, Toyoda A, Taylor TD, Itoh T, Tsai SF, Park HS, Yaspo ML, Lehrach H, Chen Z, Fu G, Saitou N, Osoegawa K, de Jong PJ, Suto Y, Hattori M, & Sakaki Y. (2002) Construction and analysis of the first human-chimpanzee comparative clone map. Science 295:131-134.
    27. Chang YT, Tsai SF, Lee DD, Shiao YM, Huang CY, Liu HN, Wang WJ & Wong CK. A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (2003) British Journal of Dermatology. 148(3):418-423.
    28. Chang YT, Tsai SF, Lin MW, Liu HN, Lee DD, Shiao YM, Chin PJ, & Wang WJ. SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene. (2003) Experimental Dermatology. 12:307-314.
    29. Chen CY*, Wu KM*, Chang YC, Chang C-H, Tsai HC, Liao TL, Liu YM, Chen HJ, Shen Arthur BT, Li JC, Su TL, Shao CP, Lee CT, Hor LI, & Tsai SF.Comparative genome analysis of Vibrio vulnificus, a marine pathogen. (2003) Genome Research 13: 2577-2587.
    30. Liu MT*, Su JS*, Huang CY & Tsai SF. Novel Mutations Involving the NF1 Gene Coding Sequence in Neurofibromatosis Type 1 Patients from Taiwan. (2003) J Hum Genet. 48(10):545-549.
    31. Sakaki Y, Watanabe H, Taylor T, Hattori M, Fujiyama A, Toyoda A, Kuroki Y, Itoh T, Saitou N, Oota S, Kim CG, Kitano T, Lehrach H, Yaspo ML, Sudbrak R, Kahla A, Reinhardt R, Kube M, Platzer M, Taenzer S, Galgoczy P, Kel A, Bloecker H, Scharfe M, Nordsiek G, Hellmann I, Khaitovich P, Paabo S, Chen Z, Wang SY, Ren SX, Zhang XL, Zheng HJ, Zhu GF, Wang BF, Zhao GP, Tsai SF, Wu K, Liu TT, Hsiao KJ, Park HS, Lee YS, Cheong JE, Choi SH; Chimpanzee Chromosome 22 Sequencing Consortium. Human versus chimpanzee chromosome-wide sequence comparison and its evolutionary implication. (2003) Cold Spring Harb Symp Quant Biol. 68:455-460.
    32. Jong YJ, Li LH, Tsou MH, Chen YJ, Cheng SH, Wang-Wuu S, Tsai SF, Chen CM, Huang AT, Hsu MT & Lin CH. Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations. (2004) Cancer Genet Cytogenet. 148(1):55-65.
    33. Huang CJ, Chen CY, Chen HH, Tsai SF & Choo KB. TDPOZ, a family of bipartite animal and plant proteins that contain the TRAF(TD) and POZ/BTB domains. (2004) Gene 324:117-127.
    34. Li LH, Li JC, Lin YF, Lin CY, Chen CY & Tsai SF. Genomic shotgun array: a procedure linking large-scale DNA sequencing with regional transcript mapping. (2004) Nucleic Acids Res.32(3):E27.
    35. Yeh SH, Wang HY, Tsai CY, Kao CL, Yang JY, Liu HW, Su IJ, Tsai SF, Chen DS, Chen PJ, The National Taiwan University SARS Research Team, Chen DS, Lee YT, Teng CM, Yang PC, Ho HN, Chen PJ, Chang MF, Wang JT, Chang SC, Kao CL, Wang WK, Hsiao CH, Hsueh PR. Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution. (2004) Proc. Natl. Acad. Sci. USA. 101(8):2542-2547.
    36. The International Chimpanzee Chromosome 22 Consortium: Watanabe H, Fujiyama A, Hattori M, Taylor TD, Toyoda A, Kuroki Y, Noguchi H, BenKahla A, Lehrach H, Kube M, Sudbrak R, Taenzer S, Galgoczy P, Platzer M, Scharfe M, Nordsiek G, Blocker H, Hellmann I, Khaitovich P, Paabo S, Reinhardt R, Zheng HJ, Zhang XL, Zhu GF, Wang BF, Fu G, Ren SX, Zhao GP, Chen Z, Lee YS, Cheong JE, Choi SH, Wu KM, Liu TT, Hsiao KJ, Tsai SF, Kim CG, Oota S, Kitano T, Kohara Y, Saitou N, Park HS, Wang SY, Yaspo ML, Sakaki Y. DNA sequence and comparative analysis of chimpanzee chromosome 22. (2004) Nature 429: 382-388.
    37. Chang YT, Shiao YM, Chin PJ, Liu YL, Chou FC, Wu S, Lin YF, Li LH, Lin MW, Liu HN, Tsai SF. Genetic polymorphisms of the HCR gene and a genomic segment in close proximity to HLA-C are associated with patients with psoriasis in Taiwan. (2004) Br. J. Dermatol. 150(6):1104-1111.
    38. Bartholomay LC, Cho WL, Rocheleau TA, Boyle JP, Beck ET, Fuchs JF, Liss P, Rusch M, Butler KM, Wu RC, Lin SP, Kuo HY, Tsao IY, Huang CY, Liu TT, Hsiao KJ, Tsai SF, Yang UC, Nappi AJ, Perna NT, Chen CC, Christensen BM. Description of the Transcriptomes of Immune Response-Activated Hemocytes from the Mosquito Vectors Aedes aegypti and Armigeres subalbatus. (2004) Infect. Immun. 72(7):4114-4126.
    39. Chen WM, Liu YF, Lin MW, Chen IC, Lin PY, Lin GL, Jou YS, Lin YT, Fann CS, Wu JY, Hsiao KJ & Tsai SF. Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13. (2004) Am. J. Hum. Genet. 75(2): 310-317.
    40. Chang YT, Liu HN, Wang WJ, Lee DD, Tsai SF. A study of cytokeratin profiles in localized cutaneous amyloids. (2004) Arch. Dermatol. Res. 296(2): 83-88.
    41. Chen YT, Chang HY, Lai YC, Pan CC, Tsai SF, Peng HL. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. (2004) Gene 337:189-198.
    42. Kao WC, Chen YR, Yi EC, Lee H, Tian Q, Wu KM, Tsai SF, Yu SS, Chen YJ, Aebersold R, Chan SI. Quantitative proteomic analysis of metabolic regulation by copper ions in methylococcus capsulatus (Bath). (2004) J Biol Chem. 279(49):51554-51560.
    43. Yeh SH, Lin MW, Lu SF, Wu DC, Tsai SF, Tsai CY, Lai MY, Hsu HC, Chen DS, Chen PJ. Allelic loss of chromosome 4q21 approximately 23 associates with hepatitis B virus-related hepatocarcinogenesis and elevated alpha-fetoprotein. (2004) Hepatology. 40(4):847-854.
    44. Huang SF, Liu HP, Li LH, Ku YC, Fu YN, Tsai HY, Chen YT, Lin YF, Chang WC, Kuo HP, Wu YC, Chen YR, Tsai SF. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. (2004) Clin Cancer Res. 10(24):8195-8203.
    45. Tsai HY, Hsi BL, Hung IJ, Yang CP, Lin JN, Chen JC, Tsai SF, Huang SF. Correlation of MYCN amplification with MCM7 protein expression in neuroblastomas: a chromogenic in situ hybridization study in paraffin sections. (2004) Hum Pathol. 35(11):1397-1403.
    46. Chang YH, Su WH, Lee TC, Sun HF, Chen CH, Pan WH, Tsai SF, Jou YS. TPMD: a database and resources of microsatellite marker genotyped in Taiwanese populations. (2005) Nucleic Acids Res. Database Issue:D174-177.
    47. Lin MW, Lee DD, Lin CH, Huang CY, Wong CK, Chang YT, Liu HN, Hsiao KJ, Tsai SF. Suggestive Linkage of Familial Primary Cutaneous Amyloidosis to a Locus on Chromosome 1q23. (2005) Br J Dermatol. 152(1):29-36.
    48. Liu YF, Chen WM, Lin YF, Yang RC, Lin MW, Li LH, Chang YH, Jou YS, Lin PY, Su JS, Huang SF, Hsiao KJ, Fann CS, Hwang HW, Chen YT, Tsai SF. Type II collagen gene variants and inherited osteonecrosis of the femoral head. (2005) N Engl J Med. 352(22):2294-2301.
    49. Chou TY, Chiu CH, Li LH, Hsiao CY, Tzen CY, Chang KT, Chen YM, Perng RP, Tsai SF, Tsai CM. Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer. (2005) Clin Cancer Res. 11(10):3750-3757.
    50. Chang YT, Liu HN, Yu CW, Lin MW, Huang CH, Chen CC, Liu MT, Lee DD, Wang WJ, Tsai SF. Cytokine gene polymorphisms in bullous pemphigoid in a Chinese population. (2006) Br J Dermatol.154(1):79-84.
    51. Chen YR, Fu YN, Lin CH, Yang ST, Hu SF, Chen YT, Tsai SF, Huang SF. Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. (2006) Oncogene. 25(8):1205-1215.
    52. Chang YT, Lee WR, Yu CW, Liu HN, Lin MW, Huang CH, Chen CC, Lee DD, Wang WJ, Hu CH, Tsai SF. No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis. (2006) Clin Exp Dermatol. 31:419-423.
    53. Su JS, Tsai TF, Chang HM, Chao KM, Su TS, Tsai SF. Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression. (2006) J Biol Chem. 281:19809-19821.
    54. Hsieh MH, Fang YF, Chang WC, Kuo HP, Lin SY, Liu HP, Liu CL, Chen HC, Ku YC, Chen YT, Chang YH, Chen YT, Hsi BL, Tsai SF, Huang SF. Complex Mutation Patterns of Epidermal Growth Factor Receptor Gene Associated with Variable Responses to Gefitinib Treatment in Patients with Non-Small Cell Lung Cancer. (2006) Lung Cancer 53(3):311-322.
    55. Chang YT, Chou CT, Shiao YM, Lin MW, Yu CW, Chen CC, Huang CH, Lee DD, Liu HN, Wang WJ, Tsai SF. The killer cell immunoglobulin-like receptor genes do not confer susceptibility to psoriasis vulgaris independently in Chinese. (2006) J Invest Dermatol. 126(10):2335-2338.
    56. Chang YT, Chou CT, Shiao YM, Lin MW, Yu CW, Chen CC, Huang CH, Lee DD, Liu HN, Wang WJ, Tsai SF. Psoriasis vulgaris in Chinese is associated with PSORS1C3 and CDSN genes. (2006) Br J Dermatol. 155(4):663-669.
    57. Lee DD, Lin MW, Chen IC, Huang CY, Liu MT, Wang CR, Chang YT, Liu HN, Liu TT, Wong CK, Tsai SF. Genome-Wide Scan Identifies a Susceptibility Locus for Familial Primary Cutaneous Amyloidosis on Chromosome 5p13.1-q11.2. (2006) Br J Dermatol. 155(6):1201-8.
    58. Chen YT, Shu HY, Li LH, Liao TL, Wu KM, Shiau YR, Yan JJ, Su IJ, Tsai SF, Lauderdale TL. Complete Nucleotide Sequence of pK245, a 98-Kilobase Plasmid Conferring Quinolone Resistance and Extended-Spectrum-{beta}-Lactamase Activity in a Clinical Klebsiella pneumoniae Isolate. (2006) Antimicrob Agents Chemother. 50(11):3861-3866.
    59. Hung KW, Lin YC, Cheng CC, Fan PJ, Chang CF, Tsai SF, Huang TH. Resonance assignments of a CoA binding protein from Klebsiella pneumoniae. (2006) J Biomol NMR. 36(5):74.
    60. Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK. Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates. (2006) PLoS Biol. 5(2):e13 [Epub ahead of print]
    61. Chang YT, Hsu CY, Chou CT, Lin MW, Shiao YM, Tsai CY, Yu CW, Shiue JJ, Lee YF, Huang CH, Chen CC, Lee DD, Wang WJ, Liu HN, Tsai SF. The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. (2007) J Dermatol Sci. [Epub ahead of print]
  • Conference Papers
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